Two Doses Of Sputnik V Covid Vaccine Effective Against Omicron: Study

According to a brief research, individuals who took two doses of Russia’s Sputnik V inoculation had lower levels of Omicron-neutralizing antibodies than those who received Pfizer jabs.

The combined Russian-Italian researchers assessed blood serum samples obtained three to six months after the second dosage of the two vaccines, which was financed by the Russian Direct Investment Fund, which offers Sputnik V.

Scientists from the Spallanzani Institute in Italy and the Gamaleya Institute in Russia, the vaccine’s inventor, undertook the yet-to-be peer-reviewed research, which was published on the preprint repository MedRxiv on January 19.

According to the research, the Sputnik V vaccine produces over two times the amount of virus neutralising antibodies to the Omicron variant than two doses of the Pfizer vaccine, according to the study.

The study used blood samples from 51 people who were inoculated with Sputnik V and 17 people who were inoculated with the Pfizer preventative, all of whom had equal levels of neutralising antibodies against the initial Wuhan variation.

The authors of the research noted that “Sputnik V shows significantly smaller (2.6 times) reduction of virus neutralising activity against Omicron as compared to reference Wuhan variant.”

“The vaccine showed an 8.1-fold reduction of virus neutralising activity against Omicron as against 21.4-fold reduction for Pfizer vaccine, ” they said.

“Among the top quartile of individuals with high receptor-binding domain (RBD)-specific IgG antibodies, 100 per cent of those vaccinated with Sputnik V were able to neutralise Omicron variant in comparison to 83.3 per cent of individuals vaccinated with Pfizer,” the researchers noted.

According to the research, Sputnik V neutralises the Omicron variation by eliciting a strong antibody response with high levels of protection.

RBD is a protein found on the “spike” protein of a virus that permits it to access and infect human cells.

“Among all samples, 74.2 per cent of Sputnik V-vaccinated sera were able to neutralise Omicron vs. 56.9 per cent for Pfizer-vaccinated,” they added.

A previous study published on MedRxiv by the Gamaleya Institute found that a booster shot of Sputnik Light vaccination provided a higher antibody response against Omicron than the two-dose Sputnik V vaccine alone.

Today, the necessity of third booster vaccination is obvious. And the most effective approach, already shown in several studies, is the use of heterologous booster vaccination pioneered in COVID-19 vaccines by Sputnik V,”  the authors of the research added.